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Main Street is a satirical novel written by Sinclair Lewis, and published in 1920.

Carol Milford is a liberal, free-spirited young woman, reared in the metropolis of Minneapolis. She marries Will Kennicott, a doctor, who is a small-town boy at heart.

When they marry, Will convinces her to live in his home-town of Gopher Prairie, Minnesota. Carol is appalled at the backwardness of Gopher Prairie. But her disdain for the town's physical ugliness and smug conservatism compels her to reform it. . . .

Main Street was initially awarded the 1921 Pulitzer Prize for literature, but was rejected by the Board of Trustees, who overturned the jury's decision. The prize went, instead, to Edith Wharton for The Age of Innocence. In 1926 Lewis refused the Pulitzer when he was awarded it for Arrowsmith.

In 1930, Lewis was the first American ever awarded the Nobel Prize for Literature. While a Nobel Prize is awarded to the author not the work, and itself does not cite a particular work for which he was chosen, Main Street was Lewis' best-known work and enormously popular at the time. In the Nobel committee's presentation speech, both Main Street and Arrowsmith were cited.

Harry Sinclair Lewis (1885-1951) was an American novelist, short-story writer, and playwright.

In 1930, he became the first writer from the United States to receive the Nobel Prize in Literature, which was awarded "for his vigorous and graphic art of description and his ability to create, with wit and humor, new types of characters."

His works are known for their insightful and critical views of American capitalism and materialism between the wars. He is also respected for his strong characterizations of modern working women.